Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

___________________________________________

Monday, December 28, 2009

Variant in PNPLA3 is associated with alcoholic liver disease


Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels.

We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence.

We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis.

Read Full Abstract

Request Reprint E-Mail: david_hinds@perlegen.com
______________________________________
at