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Sunday, August 23, 2009

May an alcohol induced increase of HDL be considered as atheroprotective
Physiological research / Academia Scientiarum Bohemoslovaca 12 August 2009

It is well known that the consumption of moderate doses of alcohol leads to increase of HDL cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT).

In the study with a cross-over design 13 male volunteers were studied in two different regimens: i) drinking of 36 gr alcohol daily and ii) drinking only on-alcoholic beverages, to test whether alcohol induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labelled human macrophages.

Moderate alcohol consumption changes the capacity of plasma to induce CHE only at a border line significance.

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