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Friday, May 15, 2009

Prevention Effects Moderate the Association of 5-HTTLPR and Youth Risk Behavior Initiation: Gene × Environment Hypotheses Tested via a Randomized Prevention Design
Child Development Volume 80 Issue 3, Pages 645 - 661

A randomized prevention design was used to investigate a moderation effect in the association between a polymorphism in the SCL6A4(5HTT) gene at 5-HTTLPR and increases in youths' risk behavior initiation.

Risk behavior initiation across 29 months was linked positively with the 5-HTTLPR genotype and negatively with SAAF participation. Control youths at genetic risk initiated risk behavior at twice the rate of SAAF youths at genetic risk and youths not at genetic risk in either condition.


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