Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Tuesday, September 20, 2011

JRF report: Young people, alcohol and the media


A new study by The Centre for Public Health at Liverpool John Moores University for the Joseph Rowntree Foundation (JRF) explores media representations of alcohol and their influence on teenage drinking.

Download Young people, alcohol and the media or access the summary here. > > > > Read More

Monday, September 19, 2011

Editorial: Alcohol program an example for campuses


We support the University of Wisconsin-Madison's policy that requires students who commit alcohol-related violations to take a class aimed at educating them about potential dangers of alcohol misuse.

Northeastern Wisconsin contributes significantly to the UW-Madison student body, so efforts to address a social problem can strike close to home. If the policy produces positive results, it may be something for UW-Green Bay to consider, even though its campus size and climate differ greatly from Madison.

The policy was developed by the Chancellor's Alcohol Policy Group in cooperation with University Health Services. The required class is called BASIC — Brief Alcohol Screening and Intervention for College Students — and gives students the option of participating in a group session (two 90-minute programs costing $78) or two one-on-one programs with a professional substance abuse counselor for $200.

The cost is in addition to the fines students have to pay for underage drinking citations or any other alcohol-related offense. > > > > Read More

Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous: a multiple mediator analysis



Evidence indicates that Alcoholics Anonymous (AA) participation reduces relapse risk but less is known about the mechanisms through which AA confers this benefit. Initial studies indicate self-efficacy, negative affect, adaptive social networks and spiritual practices are mediators of this effect, but because these have been tested in isolation, their relative importance remains elusive. This study tested multiple mediators simultaneously to help determine the most influential pathways.

Prospective, statistically controlled, naturalistic investigation examined the extent to which these previously identified mechanisms mediated AA attendance effects on alcohol outcomes controlling for baseline outcome values, mediators, treatment, and other confounders.

Nine clinical sites within the United States.

Adults (n = 1726) suffering from alcohol use disorder (AUD) initially enrolled in a randomized study with two arms: aftercare (n = 774); and out-patient (n = 952) comparing three out-patient treatments (Project MATCH).


AA attendance during treatment; mediators at 9 months; and outcomes [percentage of days abstinent (PDA) and drinks per drinking day (DDD)] at 15 months.

Among out-patients the effect of AA attendance on alcohol outcomes was explained primarily by adaptive social network changes and increases in social abstinence self-efficacy. Among more impaired aftercare patients, in addition to mediation through adaptive network changes and increases in social self-efficacy, AA lead to better outcomes through increasing spirituality/religiosity and by reducing negative affect. The degree to which mediators explained the relationship between AA and outcomes ranged from 43% to 67%.

While Alcoholics Anonymous facilitates recovery by mobilizingFont size several processes simultaneously, it is changes in social factors which appear to be of primary importance.



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Request Reprint E-Mail: jkelly11@partners.org



Press Release - Distinguished IU scientists awarded IU President's Medal


Indiana University President Michael A. McRobbie has awarded emeriti faculty members John Preer and Ting-Kai Li with the President's Medal for Excellence. The awards are among the highest honors an IU president can bestow. > > > > Read More

Mindfulness and modification therapy for behavioral dysregulation: results from a pilot study targeting alcohol use and aggression in women†


Objectives: Increasing evidence suggests that deficits in mindfulness (awareness, attentiveness, and acceptance of the present moment) play a role in a range of disorders involving behavioral dysregulation. This paper adds to that literature by describing a transdiagnostic psychotherapy (Mindfulness & Modification Therapy; MMT) developed to target behavioral dysregulation.

An open-treatment pilot-trial investigated the feasibility, acceptability, and pre-post effects of MMT targeting women (N = 14) court-referred for alcohol abuse/dependence and aggression.

Pre-post comparisons revealed significant decreases in alcohol use, drug use, and aggression. In addition, the retention rate was 93%.


Preliminary evidence suggests that MMT is a feasible and acceptable treatment that decreases dysregulated behaviors such as substance use and aggression, while also potentially increasing retention.



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Request Reprint E-Mail: pegwupp@hotmail.com

Press Release - UN General Assembly announces historic commitment to fight noncommunicable diseases


WHO welcomes the adoption today by the UN General Assembly of the political declaration on the prevention and control of noncommunicable diseases such as diabetes, heart disease and stroke, chronic respiratory disease and cancer which together kill some 36 million people each year. For the first time, global leaders have reached consensus in the General Assembly on concrete actions to tackle these diseases.

Governments agreed on the need for global targets to monitor these diseases and their risk factors like tobacco use, unhealthy diet, physical inactivity and the harmful use of alcohol. The UN General Assembly has asked WHO to develop a framework for monitoring global progress and to prepare, before the end of 2012, recommendations for a set of global targets to monitor trends and assess the progress in countries to reduce the toll of suffering, disability and premature death due to these diseases. > > > > Read More

Ethanol metabolism activates cell cycle checkpoint kinase, Chk2



Chronic ethanol abuse results in hepatocyte injury and impairs hepatocyte replication. We have previously shown that ethanol metabolism results in cell cycle arrest at the G2/M transition, which is partially mediated by inhibitory phosphorylation of the cyclin-dependent kinase, Cdc2.

To further delineate the mechanisms by which ethanol metabolism mediates this G2/M arrest, we investigated the involvement of upstream regulators of Cdc2 activity.

Cdc2 is activated by the phosphatase Cdc25C. The activity of Cdc25C can, in turn, be regulated by the checkpoint kinase, Chk2, which is regulated by the kinase ataxia telangiectasia mutated (ATM).

To investigate the involvement of the regulators of Cdc2 activity, VA-13 cells, which are Hep G2 cells modified to efficiently express alcohol dehydrogenase, were cultured in the presence or absence of 25 mM ethanol. Immunoblots were performed to determine the effects of ethanol metabolism on the activation of Cdc25C, Chk2, and ATM.

Ethanol metabolism increased the active forms of ATM and Chk2, as well as the phosphorylated form of Cdc25C. Additionally, inhibition of ATM resulted in approximately 50% of the cells being rescued from the G2/M cell cycle arrest and ameliorated the inhibitory phosphorylation of Cdc2.

Our findings demonstrated that ethanol metabolism activates ATM. ATM can activate the checkpoint kinase Chk2, resulting in phosphorylation of Cdc25C and ultimately in the accumulation of inactive Cdc2.

This may, in part, explain the ethanol metabolism–mediated impairment in hepatocyte replication, which may be important in the initiation and progression of alcoholic liver injury.




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Request Reprint E-Mail: dclemens@unmc.edu

Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress



The swim-test susceptible (SUS) line of rats has been bred in our laboratory for the characteristic of reduced motor activity in the swim test following exposure to an acute stressor. Testing of multiple generations of SUS rats has also revealed that they consume large amounts of ethanol voluntarily. As reported for lines of rats that show a propensity for high-ethanol intake, the SUS rats show evidence of low serotonergic function.

Because serotonergic function has often been shown to be involved in the regulation of alcohol consumption, here we examined the effects of manipulations of serotonin transmission on intake of ethanol by SUS rats.

Fenfluramine, a serotonin-releasing drug, was injected at various doses (0.625, 1.25, 2.5, and 5.0
mg/kg) twice per day and ethanol intake was measured using a two-bottle free-choice method. The 8-OH-DPAT, a 5‑HT1A agonist, was injected at various doses (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1.0mg/kg) before a 1-h session of exposure to ethanol (single-bottle test, water available the other 23h per day). A diet enriched with 3% tryptophan (TRP), the amino acid precursor for serotonin synthesis, was administered in a restricted feeding schedule (5h per day) with ethanol intake measured the last 4h.

Fenfluramine decreased ethanol intake at all doses tested. The 8-OH-DPAT increased ethanol intake at lower doses, presumably acting at autoreceptors, which inhibit serotonergic neurons, and decreased intake at higher doses, presumably acting at postsynaptic 5-HT
1A receptors. TRP-enriched diet also significantly decreased ethanol intake. Food and water intake were less or unaffected by these three manipulations.

With all three manipulations, ethanol intake remained suppressed one or more days after the day of tests that decreased ethanol intake.

These data suggest that SUS rats, like many other lines/strains of rodents that consume large amounts of alcohol, show an inverse relationship between serotonin transmission and voluntary intake of ethanol.




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Request Reprint E-Mail: cwest@emory.edu

An in vitro model for studying the effects of continuous ethanol exposure on N-methyl-d-aspartate receptor function



Long-term ethanol exposure has deleterious effects on both glial and neuronal function. We assessed alterations in both astrocytic and neuronal viability, and alterations in N-methyl-d-aspartate receptor (NMDAR) function, in cocultures of rat cerebellar granule cells (CGCs) and astrocytes after continuous ethanol exposure (CEE).

Treatment of cells with 100 mM EtOH once every 24 h for 4 days resulted in a mean ethanol concentration of 57.3 ± 2.1 mM. Comparisons between control and post–ethanol-treated cells were made 4 days after the last ethanol treatment.

CEE did not alter glial cell viability, as indicated by the absence of either changes in astrocytic morphology, actin depolymerization, or disruption of astrocytic intracellular mitochondrial distribution at any day postethanol treatment. The CGCs were healthy and viable after CEE, as indicated by phase-contrast microscopy and the trypan-blue exclusion method.

Whole-cell patch-clamp experiments indicated that NMDA-induced currents (I
NMDA) were altered by CEE treatment. Similar to previous results obtained during the withdrawal phase from chronic ethanol exposure, INMDA from CEE-treated cells were significantly larger than INMDA from NMDARs in control CGCs, but returned to control values by the fourth day post-CEE.

However, after the last ethanol dosing and during a time when ethanol concentrations remained high, I
NMDA were significantly smaller than control values.

Identical results were observed in CGCs expressing the NR2A or NR2B subunit. In summary, both neurons and astrocytes remained healthy following exposure to CEE with no signs of neurotoxicity at the cellular level, and modulation of NMDAR function is consistent with findings from prior experiments.

Thus, we conclude that the CEE paradigm in glial–neuronal cocultures readily lends itself to long-term in vitro studies of ethanol effects that include glial–neuronal interactions and the ability to study ethanol withdrawal-induced neurotoxicity.




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Request Reprint E-Mail: lisa.popp@TTUHSC.edu

Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinki



The Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study sought to answer questions about the benefits of combining behavioral and pharmacological interventions (naltrexone and acamprosate) in alcohol-dependent patients.

Our goals were to identify trajectories of heavy drinking before randomization in COMBINE, to characterize patients in these trajectories, and to assess whether prerandomization trajectories predict drinking outcomes.

We analyzed daily indicators of heavy drinking 90 days before randomization using a trajectory-based approach. Each patient was assigned to the most likely prerandomization heavy-drinking trajectory, and the baseline characteristics of participants in the baseline trajectories were compared.

The main and interactive effects of these trajectories and treatment factors (acamprosate, naltrexone, or combined behavioral intervention) on summary drinking measures during active treatment (16 weeks) were assessed.

We identified five trajectories of heavy drinking prerandomization: “T1: frequent heavy drinkers”; “T2: very frequent heavy drinkers”; “T3: nearly daily heavy drinkers”; “T4: daily heavy drinkers”; and “T5: daily heavy drinkers stopping early” before randomization.

Trajectory membership was significantly associated with all drinking outcomes. Patients in “T5: daily heavy drinkers stopping early” had comparable drinking outcomes to those in “T1: frequent heavy drinkers,” whereas the remaining trajectories were associated with significantly worse outcomes. The baseline trajectory did not interact significantly with the treatment condition.

These exploratory analyses confirmed the hypothesis that baseline trajectories predict postrandomization drinking outcomes. Interestingly, “T5: daily heavy drinkers stopping early” had outcomes that were comparable to the least severe baseline trajectory “T1: frequent heavy drinkers,” and baseline trajectories of heavy drinking did not moderate the treatment effects.




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Request Reprint E-Mail: ralitza.gueorguieva@yale.edu

Publication trends in addiction research



As opportunities to use and abuse drugs have tremendously increased during the past 50 years, so has addiction research.

Here, we provide a systematic review on publication trends in the addiction research field. We examined publication trends in different subject categories of journals including general and multi-disciplinary science, neuroscience, pharmacology, psychiatry and, as a final and most important category, substance abuse.

In this first report, we provide a brief comprehensive overview on what has been published in terms of addiction in the general and multi-disciplinary science category versus Addiction Biology within the past decade.

We reviewed the literature within three time windows 1999/2000, 2004/2005 and 2009/2010 and selected the number of publications (1) according to the country/region where the original study was conducted; (2) according to the drug classes; (3) according to animal versus human studies; (4) and in terms of methodological trends such as genetic association studies and neuro-imaging.

We found a 350% increase in addiction-related publications in the general and multi-disciplinary science category within the past decade. This increase, however, was mainly due to increased publication output from the United States.

Concerning drug classes, alcohol-, nicotine- and psychostimulant-related publications clearly increased between 1999 and 2010, whereas published papers related to opioids decreased over time. There were also strongly increasing trends for genetic and imaging studies in the addiction field over time.

These publication trends are also reflected to a certain degree by published studies in Addiction Biology.


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Request Reprint E-Mail: rainer.spanagel@zi-mannheim.de

Optogenetics: potentials for addiction research



Research on the biology of addiction has advanced significantly over the last 50 years expanding our understanding of the brain mechanisms underlying reward, reinforcement and craving. Novel experimental approaches and techniques have provided an ever increasing armory of tools to dissect behavioral processes, neural networks and molecular mechanisms.

The ultimate goal is to reintegrate this knowledge into a coherent, mechanistic framework of addiction to help identify new treatment. This can be greatly facilitated by using tools that allow, with great spatial and temporal specificity, to link molecular changes with altered activation of neural circuits and behavior. Such specificity can now be achieved by using optogenetic tools.

Our review describes the general principles of optogenetics and its use to understand the links between neural activity and behavior. We also provide an overview of recent studies using optogenetic tools in addiction and consider some outstanding questions of addiction research that are particularly amenable for optogenetic approaches.




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Link
Request Reprint E-Mail: zs220@cam.ac.uk

Genetic variations in the dopaminergic system and alcohol use: a system-level analysis



Alcohol use is highly heritable and has been associated with many gene variants, including those related to dopamine (DA). However, single gene association studies have shown inconsistent and small effects.

Using a system-level approach, the current study aimed to estimate the overall effect of genetic variations in the DA system on alcohol use among male drinkers.

One hundred seventy-six male college students who reported to have ever drunk alcohol were enrolled. Alcohol use was measured using the Alcohol Use Disorders Identification Test. Ninety-eight representative polymorphisms in all major DA neurotransmitter genes were genotyped.

Using analysis of variance, we identified six single-nucleotide polymorphisms (SNP)s that made statistically significant contributions to alcohol use. Next, main effects and interactions of these SNPs were assessed using multiple regression. The final model accounted for approximately 20% of the variance for alcohol use. Finally, permutation analyses ascertained the probability of obtaining these findings by chance to be low,
p ranging from 0.024 to 0.048.

These results confirmed that DA-related gene variants made strong contributions to reported alcohol use and suggest that multiple regression can be a promising way to explore the genetic basis for multi-gene-determined human behaviors.


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Request Reprint E-Mail:
dongqi@bnu.edu.com

Alcohol News - 38/2011




prMac (Latvia) - DrinkControl Lite - Track Drinks and Related Expenses on iPhone for Free
Happy Moments today is pleased to announce DrinkControl Lite 2.0.345, alcohol usage and expenses tracker for iPhone. DrinkControl Lite is used for recording the beverages taken and related expenses.
Read more
Helsingin Sanomat (Finland) - Rise in alcohol tax is to focus specifically on milder drinks
Federation of the Brewing and Soft Drinks Industry assumes that the aim is to make room for Class-2 beer with lower alcohol content.
Read more
Hartwall (Finland) - Preliminary Inspection Committee supervises the TV alcohol advertising of members of the Federation of the Brewing and Soft Drinks Industry
Last spring, the Finnish Federation of the Brewing and Soft Drinks Industry decided that the content of the TV alcohol advertisements of its members will be inspected before release.
Read more
www.stockholmnews.com (Sweden) - Alcohol will be permitted at old peoples´ homes
The four parties in the government all open up for a change in the law which will permit serving alcohol at old peoples’ homes.
Read more
BakuToday (Lithuania) - The Government intends to put Lithuania in the category of moderate drinkers States
The Lithuanian Government approved the draft programme for the control of producers of alcohol and tobacco, reported today, 12 September BakuToday the press service of the Cabinet of Ministers.
Read more
The Guardian (UK) - Price of alcohol is 'obscenely low'
The price of alcohol is "obscenely low" and heavy drinkers are being subsidised by ordinary shoppers in supermarkets, according to medical experts.
Read more
Cancer Research UK - New insight into how alcohol is linked to breast and liver cancers
A US laboratory study has revealed how the breakdown of alcohol in human cells results in DNA damage that causes cell changes linked to cancer.
Read more
The Age (Australia) - Experts see red over wine 'myth'
RED wine's reputation for preventing heart attacks has come under fire from health experts who have declared every drink of alcohol can do you damage.
Read more
CNN International - WHO outlines steps to reduce leading causes of death
To decrease deaths from noninfectious diseases, countries should pass excise taxes on tobacco and alcohol, encourage smoke-free public places, reduce salt and trans fat in foods, and increase awareness of diet and physical activity, according to a World Health Organization report.
Read more
Daily Mail - Sport and demon drink: Alcohol is a poison, adding to the risk of injury
Drinking excessively in modern sport goes against everything you are taught, so what England's players have apparently been doing in New Zealand makes no sense. Alcohol is a poison, so you don't want it in your blood and when it is, you are putting yourself at severe risk of injury.
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WebMD (USA) - Drinking on the Rise Among U.S. Women
Women are catching up to men when it comes to how much and how often they drink alcohol. As a result, they are increasingly at risk for developing alcohol problems.
Read more
AllAfrica.com (Zimbabwe) - Alcohol, Tobacco Taxes to Go Up
CONCERNED by the high prevalence of non-communicable diseases, the Government is considering raising alcohol and tobacco taxes to finance the prevention and treatment of such conditions.
Read more
Los Angeles Times (USA) - Drinking problems have increased in last 60 years
An analysis of 31 studies on alcohol drinking patterns worldwide has found that people born in North America after World War II are more likely than other groups to engage in binge drinking and develop alcoholism. Younger groups consistently consume more alcohol than older generations.
Read more
Voxy (New Zealand) - Alcohol Reform Bill not to pass before election
The Government is maintaining its impotent response to New Zealand's heavy drinking culture and not even passing the Alcohol Reform Bill before the election, says Alcohol Action.
Read more
Indiana Public Media - Study: Parents Have Misperception Of Kids’ Drug, Alcohol Use
A new study looks at parents’ perception of alcohol and marijuana use among teenagers. The study from the University of Michigan’s C.S. Mott Children’s Hospital says that 10 percent of parents think their own teens drank alcohol in the last year and five percent think their teens smoked marijuana in the last year.
Read more
Sydney Morning Herald - UN summit targets obesity, alcohol and smoking
WORLD leaders will agree to a deal at a United Nations meeting tomorrow to try to curb the spread of preventable ''lifestyle'' diseases, amid concern that progress is already being hampered by powerful food, alcohol and tobacco lobbyists.
Read more
Radio-Info.com - New study: "Young people are being overexposed to alcohol ads on the radio"
There could be implications for radio advertising in this story. A 2003 deal obligated beer and distilled spirits advertisers to keep alcohol ads away from media where those under the age of 21 are particularly likely to be represented.
Read more
Independent Online (South Africa) - Hope for alcohol syndrome babies
For the first time, many South African babies born with foetal alcohol syndrome (FAS) will be diagnosed at birth – giving them a far better chance at getting help.
Read more
Sydney Morning Herald (Russia) - Beer's no longer lunch for Russians
WITH a stroke of the presidential pen, beer has been reclassified as an alcoholic drink instead of a foodstuff in Russia.
Read more
Telegraph.co.uk (UK) - Boris Johnson: 'stay sober, stay free from jail' says London mayor
In a column for The Daily Telegraph, the mayor of London called for the introduction of mandatory “sobriety tests”, instead of jail for those convicted of alcohol-fuelled violence.
Read more
U.S. News & World Report - Problem Drinking Linked to Brain Damage
Long-term alcohol abuse can result in significant damage to the brain, a new study shows.
Read more
AFP (Russia) - Russia targets beer in fight against alcoholism
With a stroke of the presidential pen, beer was recently reclassified as an alcoholic drink in Russia, no longer a foodstuff, and its sales are to be restricted to cut alcohol abuse.
Read more
Times of Malta (Malta) - Penalties on sale of alcohol to minors should be raised – MHRA
Penalties governing the sale of alcohol to minors should be raised substantially to a level that constituted a real deterrent, as had been announced by government in May this year, the Malta Hotels and Restaurants Association said.
Read more
Irish Times (Europe) - Europeans 'heaviest drinkers in world'
The World Health Organisation have announced an "action plan to reduce the harmful use of alcohol" in Europe, which they say is the heaviest drinking region in the world.
Read more
European Public Health Alliance (WHO Europe) - New Action Plan to reduce the harmful use of alcohol adopted by 53 countries in Europe
Representatives from the 53 WHO European Region Member States met at the 61st session of the Regional Committee for Europe and adopted the European Action Plan to reduce the harmful use of alcohol.
Read more
The Chosun Ilbo (Korea) - Koreans Biggest Drinkers in Asia
Koreans drink more alcohol than any of their Asian neighbors, according to the World Health Organization. According to a report the WHO released in February on the annual average per capita consumption of alcohol by country, Koreans consume 14.80 liters to rank 13th in the world and No. 1 in Asia. The results were based on data gathered from 2003 to 2005.
Read more


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Alcohol, Tobacco Taxes to Go Up


CONCERNED by the high prevalence of non-communicable diseases, the Government is considering raising alcohol and tobacco taxes to finance the prevention and treatment of such conditions.

The move will push retail prices of the products upwards.

Speaking ahead of the United Nations High-Level Meeting on NCDs, which begins here today, Health and Child Welfare Minister Dr Henry Madzorera said he would present the proposals to Cabinet after the Summit. > > > > Read More

National A.A. Archives Workshop




September 22-25, 2011
Helena, Montana


Registration

Disease-driven detection of differential inherited SNP modules from SNP network



Detection of the synergetic effects between variants, such as single-nucleotide polymorphisms (SNPs), is crucial for understanding the genetic characters of complex diseases.

Here, we proposed a two-step approach to detect differentially inherited SNP modules (synergetic SNP units) from a SNP network. First, SNP–SNP interactions are identified based on prior biological knowledge, such as their adjacency on the chromosome or degree of relatedness between the functional relationships of their genes. These interactions form SNP networks. Second, disease-risk SNP modules (or sub-networks) are prioritised by their differentially inherited properties in IBD (Identity by Descent) profiles of affected and unaffected sibpairs.

The search process is driven by the disease information and follows the structure of a SNP network. Simulation studies have indicated that this approach achieves high accuracy and a low false-positive rate in the identification of known disease-susceptible SNPs.

Applying this method to an alcoholism dataset, we found that flexible patterns of susceptible SNP combinations do play a role in complex diseases, and some known genes were detected through these risk SNP modules.

One example is
GRM7, a known alcoholism gene successfully detected by a SNP module comprised of two SNPs, but neither of the two SNPs was significantly associated with the disease in single-locus analysis. These identified genes are also enriched in some pathways associated with alcoholism, including the calcium signalling pathway, axon guidance and neuroactive ligand–receptor interaction.

The integration of network biology and genetic analysis provides putative functional bridges between genetic variants and candidate genes or pathways, thereby providing new insight into the aetiology of complex diseases
.



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Request Reprint E-Mail: lixia@hrbmu.edu.cn

Genes and Pathways Co-associated with the Exposure to Multiple Drugs of Abuse, Including Alcohol, Amphetamine/Methamphetamine, Cocaine, Marijuana, Mor



Drug addiction is a chronic neuronal disease. In recent years, proteomics technology has been widely used to assess the protein expression in the brain tissues of both animals and humans exposed to addictive drugs. Through this approach, a large number of proteins potentially involved in the etiology of drug addictions have been identified, which provide a valuable resource to study protein function, biochemical pathways, and networks related to the molecular mechanisms underlying drug dependence.

In this article, we summarize the recent application of proteomics to profiling protein expression patterns in animal or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine.

From available reports, we compiled a list of 497 proteins associated with exposure to one or more addictive drugs, with 160 being related to exposure to at least two abused drugs.

A number of biochemical pathways and biological processes appear to be enriched among these proteins, including synaptic transmission and signaling pathways related to neuronal functions.

The data included in this work provide a summary and extension of the proteomics studies on drug addiction. Furthermore, the proteins and biological processes highlighted here may provide valuable insight into the cellular activities and biological processes in neurons in the development of drug addiction.



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Request Reprint E-Mail: Ming_Li@virginia.edu

FASD News - 37/2011


FemaleFirst.co.uk - Alcohol in pregnancy causes 'most common form of learning disability'
A new research paper has assessed the impact on learning of children suffering from foetal alcohol spectrum disorder (FASD) and it provides a wake-up call to the consequences of drinking alcohol whilst pregnant.
Read more
The West Australian (Australia) - Alcohol in pregnancy can harm babies
Fetal Alcohol Spectrum Disorder is now being revealed as a tragic legacy of alcohol misuse. And the condition is not isolated to marginalised, disadvantaged communities, researchers say.
Read more
BBC News (UK) - Pregnant pause at Aberdeen flash gathering
A flash mob to highlight fetal alcohol problems has taken place in Aberdeen city centre.
Read more
EMC Kingston (Canada) - A resounding reminder of the dangers of alcohol consumption during pregnancy
Who better to help ring a bell to raise awareness about any worthwhile cause than the city's own Town Crier, Chris Whyman. Wyman, bell in hand, joined a room full of people at Kingston, Frontenac, Lennox and Addington Public Health as they rang bells to raise awareness about Fetal Alcohol Spectrum Disorder (FASD).
Read more
WVNS (USA) - Born Addicted: Approximately 1 out of 5 W.Va. Babies Born With Drugs in System
Instead of spending the first few weeks or months in the comfort of their new home, many West Virginia babies start their lives in an intensive care unit, withdrawing from drugs.
Read more
Kingston This Week (Canada) - New interventions for Fetal Alcohol Syndrome
Until the last child is born with Fetal Alcohol Spectrum Disorder, bells will continue to toll around the world at 9:09 a.m. on September 9 to mark International FASD Awareness Day and the importance of abstaining from alcohol during the nine months of pregnancy.
Read more
Independent Online (South Africa) - Hope for alcohol syndrome babies
For the first time, many South African babies born with foetal alcohol syndrome (FAS) will be diagnosed at birth – giving them a far better chance at getting help.
Read more
NewsPoint Africa (South Africa) – EXPERTS acknowledge 4000 new cases fas every year says report
Foetal alcohol syndrome is a severe birth defect that makes infants mentally retarded along with episodes of facial and neural abnormalities as well as malformations of other body parts. The health condition is believed to be triggered by alcohol consumption during pregnancy.
Read more
Austin American-Statesman (USA) - State office, advocates seek screening of all pregnant women for alcohol use
A state health office and advocates announced Friday that they are seeking universal screening of all pregnant Texas women and "brief intervention for alcohol use" to prevent a widespread but little-known disability.
Read more
EurActiv (EU) - Combat alcohol abuse with mandatory labels, EU urged
Policymakers gathered in Brussels this week to discuss the risks posed by alcohol abuse to unborn children urged the EU to introduce mandatory warning labels on bottles and cans.
Read more
South Wales Argus (Wales) - Mums-to-be tell of dangers of boozing while pregnant
MUMS-to-be joined NHS staff in Newport yesterday to highlight the dangers of drinking alcohol while pregnant.
Read more
Independent Online - Just one drink can harm your unborn baby
Friday (September 9, 2011) is International Foetal Alcohol Syndrome (FAS) Awareness Day and the Industry Association for Responsible Alcohol Use (ARA) is urging expecting mothers not to drink alcohol while pregnant.
UPCOMING EVENTS
2ND International SAFFrance Colloquium, 15- 16 December 2011, Strasbourg
The second international conference of SAFFrance to be organised on the 15th and 16th of December in Strasbourg is linked to the first conference organised in the Senate in September 2009 to which the higher head of state participated.
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Live webcast – September 28, 2011 (9 -11am MST) – Talking with Women about Alcohol and Pregnancy
Christine Urqhart, Co-Founder, Change Talk Associates This session will address FASD prevention in relation to how we communicate with pregnant women and women in their childbearing years along the continuum of risk.
Read more

MATERIALS:
2011 Fetal Alcohol Canadian Expertise (FACE) Poster Competition Abstracts
Held on September 13, 2011 - Prince Edward Island
Read more
Centers for Disease Control and Prevention - Fetal Alcohol Spectrum Disorders
Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. Learn more about signs, treatments, and what you can do about FASDs.
Read more
Canadian Foundation on Fetal Alcohol Research Awards Research Grants
The Canadian Foundation on Fetal Alcohol Research (CFFAR) today announced its fourth round of grants awarded for the research, prevention and treatment of Fetal Alcohol Spectrum Disorder (FASD). Dr. Louise Nadeau, Professor at the Université de Montréal and Scientific Director of the Centre Dollard-Cormier, University Institute on Dependencies and Ian Faris, President and CEO of the Brewers Association of Canada (BAC) made the announcement.
Read more

RESEARCH:
A Differential Approach for Examining the Behavioural Phenotype of Fetal Alcohol Research Disorders
2006, Nash and colleagues published results suggesting that individual items from the Child Behavior Checklist (CBCL) could be used as a screening tool that was highly sensitive in differentiating children with FASD from controls and children with Attention Deficit Hyperactivity Disorder (ADHD).
Read more
A Need for Closer Examination of FASD by the Criminal Justice System: Has the Call Been Answered?
Individuals with FASD exhibit deficits in many domains that can include memory, learning, behavioural inhibition, executive functioning, interpersonal skills, and language. These deficits have serious implications for affected persons when they become engaged in the legal system.
Read more

IN OTHER LANGUAGES:
STERN.DE (Germany) - Für immer geschädigt
In Deutschland kommen jedes Jahr mehrere tausend Babys mit Alkoholschäden zur Welt, weil ihre Mütter während der Schwangerschaft getrunken haben. Die Kinder sind oft unterentwickelt, verhaltensauffällig und lernen nicht so schnell wie Gleichaltrige - so wie Michael Resch, für den seine Kindheit eine Qual war.
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Opoka (Poland) - Międzynarodowy Dzień FAS i konferencja w Lędzinach
W dniu 9 wrzeÅ›nia obchodzony jest po raz 11 Åšwiatowy DzieÅ„ FAS. PÅ‚odowy Zespół Alkoholowy (ang. FAS: Fetal Alcohol Syndrome) jest zespoÅ‚em uszkodzeÅ„ organizmu i zwiÄ…zanych z tym zaburzeÅ„ rozwoju u dzieci matek pijÄ…cych alkohol w czasie ciąży. W USA ten syndrom znany jest od 1973 r. W najbliższy poniedziaÅ‚ek, 12 wrzeÅ›nia odbÄ™dzie siÄ™ w LÄ™dzinach konferencja naukowa „FASD (poalkoholowe spektrum wrodzonych zaburzeÅ„ rozwojowych a inne zaburzenia rozwojowe".
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Deutsches Ärzteblatt (Germany) - Drogenbeauftragte: Gynäkologen sollen schwangere Mädchen vor Alkoholkonsums warnen
Schätzungsweise 10.000 Kinder mit einer Form der Fetalen Alkoholspektrum-Störung (FASD) werden in jedem Jahr in Deutschland geboren. Damit ist FASD die häufigste angeborene Behinderung in diesem Land.
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Salon Seudun Sanomat (Finland) - 9.9. muistuttaa yhdeksän kuukauden raittiudesta
Perjantaina vietetään kansainvälistä FASD-päivää. Päivämäärä 9.9. muistuttaa odottavan äidin yhdeksän kuukauden raittiudesta. Kun odottava äiti juo alkoholia, juo kohdussa oleva lapsikin. Alkoholi on kuitenkin myrkky, jota sikiön elimistö ei pysty käsittelemään. Vaikeimmillaan alkoholi voi aiheuttaa syntyvälle lapselle syvän kehitysvamman.
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Libero-News.it (Italy) – Pediatria Iss rischi da alcol nel pancione per oltre 7 neonati su 100
Divieto assoluto di bere alcol per le donne in gravidanza. Ma in Italia 7,6 neonati su 100 corrono il rischio di un'esposizione ai danni della sindrome fetoalcolica.
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Noticias Médicas (Spain) - El 25% de mujeres españolas aún bebe alcohol en el embarazo a pesar de las graves consecuencias para el bebé
La importancia de los trastornos derivados del consumo abusivo de bebidas alcohólicas afecta a de 2 a 4 bebés nacidos, según el Parlamente Europeo. Read more


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