Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependencePharmacogenetics and Genomics: POST AUTHOR CORRECTIONS, 1 October 2009
To examine the association between genetic variability of IL-1B, which encodes for the proinflammatory cytokine IL-1[beta] and the risk of developing opioid dependence. To confirm a previous study, we also examined the association between the IL-1B genetic polymorphism and alcohol dependence.
This study confirms the previous finding that IL-1B polymorphism is associated with altered risk of alcohol dependence. IL-1B single nucleotide polymorphisms at position -511 and -31, which increase IL-1[beta] production, occur at a higher frequency in opioid-dependent populations and may be associated, albeit weakly, with an increased risk of opioid dependence.
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