Association of the Long Allele of the 5-HTTLPR Polymorphism with Compulsive Craving in Alcohol Dependence
Alcohol and Alcoholism Advance Access published online on August 21, 2007




Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism.

The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment.

We found significantly higher compulsive craving in patients with the long allele of the 5-HTTLPR polymorphism .

Our results suggest that the long variant of the 5-HTTLPR polymorphism is associated with higher compulsive alcohol craving at the beginning of alcohol withdrawal.

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Reprint Request E-Mail: stefan.bleich@uk-erlangen.de

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