What happens when you drink alcohol?
The answer, on one level, is simple - you get drunk. But the science reveals a complicated series of reactions that lie behind drinking - between chemicals and neurons, genes and environment, people and society. Understanding these factors is important. Alcohol is implicated in 47% of violent crime in the UK and is estimated to cost the economy some £21bn a year.
The Today programme asked Sally Marlow, a researcher in alcohol addiction at King's College London, to look at the challenge of tackling alcohol abuse - and how it can best be understood - she's spent time in the north east of England.
First broadcast on BBC Radio 4's Today programme on Friday 1 March 2013.