The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues.
We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice.
We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.
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We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice.
We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.
Read Full Abstract
Request Reprint E-Mail: gremelc@mail.nih.gov