Saturday, July 3, 2010

Neuromodulation of Decision-Making in the Addictive Brain



Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects.

The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors.

We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions.

We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.



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