The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's diseaseInternational Journal of Geriatric Psychiatry Early View 14 Sep 2009
This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE 4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups.
The results suggest that APOE 4 and heavy drinking and heavy smoking lower the age of onset for AD in an additive fashion. Copyright © 2009 John Wiley & Sons, Ltd.
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