Interoceptive Effects of Alcohol Require mGlu5 Receptor Activity in the Nucleus AccumbensThe Journal of Neuroscience, July 29, 2009, 29(30):9582-9591
The interoceptive effects of alcohol are major determinants of addiction liability. Metabotropic glutamate (mGlu) receptors are widely expressed in striatal circuits known to modulate drug-seeking.
Given that the interoceptive effects of drugs can be important determinants of abuse liability, we hypothesized that striatal mGlu receptors modulate the interoceptive effects of alcohol.
These results show that mGlu5 receptor activity in the nucleus accumbens is required for the expression of the interoceptive effects of alcohol.
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