The neuropeptide Y Y1 receptor subtype is necessary for the
anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
Psychopharmacology Online Early 22 September 2007

Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY’s effects on rodent anxiety and depression-related behaviors.

These data demonstrate that Y1R is necessary for the anxiolytic-like effects of icv NPY, but not for the antidepressant-like or neurogenesis-inducing effects of fluoxetine. The present study supports targeting Y1R as a novel therapeutic target for anxiety disorders.

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Reprint Request E-Mail: karlssonr@mail.nih.gov
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