Between- and Within-Family Association Test of the Dopamine Receptor D2 TaqIA Polymorphism and Alcohol Abuse and Dependence in a General Population Sample of Adults

Volume 68, 2007 > Issue 3: May 2007

Dopaminergic dysfunction has been hypothesized to play an important role in the etiology of alcohol-use disorders.

A restriction fragment length polymorphism (RFLP) in the 3 untranslated region (3UTR) of the DRD2 gene affects gene expression and has been implicated as a risk factor for alcohol dependence.

This polymorphism (TaqIA) has been reported as positively associated with alcohol-use disorders in case-control samples, but these results have not been replicated in family-based association studies.

This study supports other family-based association tests that have reported no association between the DRD2 TaqIA polymorphism and alcohol abuse and dependence.

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